Publications

Glycerophospholipid remodeling is critical for orthoflavivirus infection
Hehner J, Schneider L, Woitalla A, Ott B, Vu KCT, Schöbel A, Hain T, Schwudke D, Herker E
Nat Commun 15(1):8683 2024
doi: 10.1038/s41467-024-52979-y PMID: 39375358 PMCID: PMC11458896

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids
Schöbel A, Pinho Dos Reis V, Burkhard R, Hehner J, Schneider L, Schauflinger M, Vieyres G, Herker E
Commun Biol 7(1):1089 2024
doi: 10.1038/s42003-024-06776-4 PMID: 39237833 PMCID: PMC11377701

3D Spheroid and Organoid Models to Study Neuroinfection of RNA Viruses
Dos Reis VP, Cirksena K, Rybak-Wolf A, Seeger B, Herker E, Gerold G
Methods Mol Biol 2824:409-424 2024
doi: 10.1007/978-1-0716-3926-9_26 PMID: 39039427

Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry
Bley H, Krisp C, Schöbel A, Hehner J, Schneider L, Becker M, Stegmann C, Heidenfels E, Nguyen-Dinh V, Schlüter H, Gerold G, Herker E
J Biol Chem 300(5):107286 2024
doi: 10.1016/j.jbc.2024.107286 PMID: 38636657 PMCID: PMC11101947

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens
Groß R, Reßin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preußer C, Seehafer K, Pöhlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Münch J, Müller JA
Nat Microbiol 9(4):905-921 2024
doi: 10.1038/s41564-024-01637-6 PMID: 38528146 PMCID: PMC10994849

Lipid Droplets in Virus Replication
Herker E
FEBS Lett 598(10):1299-1300 2024
doi: 10.1002/1873-3468.14819 PMID: 38348563

Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses
Nguyen-Dinh V, Herker E
Cells 10(9):2407 2021
doi: 10.3390/cells10092407 PMID: 34572055 PMCID: PMC8464962

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells
Schöbel A, Nguyen-Dinh V, Schumann GG, Herker E
PLoS Pathog 17(4):e1009496 2021
doi: 10.1371/journal.ppat.1009496 PMID: 33872335 PMCID: PMC8084336

Lipid Droplet Contact Sites in Health and Disease
Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M
Trends Cell Biol 31(5):345-358 2021
doi: 10.1016/j.tcb.2021.01.004 PMID: 33546922

Hepatitis E virus persists in the ejaculate of chronically infected men
Horvatits T, Wißmann JE, Johne R, Groschup MH, Gadicherla AK, Schulze Zur Wiesch J, Eiden M, Todt D, Reimer R, Dähnert L, Schöbel A, Horvatits K, Lübke R, Wolschke C, Ayuk F, Rybczynski M, Lohse AW, Addo MM, Herker E, Lütgehetmann M, Steinmann E, Pischke S
J Hepatol 75(1):55-63 2021
doi: 10.1016/j.jhep.2020.12.030 PMID: 33484776

Grease on-Perspectives in lipid droplet biology
Beller M, Herker E, Füllekrug J
Semin Cell Dev Biol 108:94-101 2020
doi: 10.1016/j.semcdb.2020.06.017 PMID: 32636101

Whole Lotta Lipids-from HCV RNA Replication to the Mature Viral Particle
Bley H, Schöbel A, Herker E
Int J Mol Sci 21;21(8):2888 2020
doi: 10.3390/ijms21082888 PMID: 32326151 PMCID: PMC7215355

Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production
Lassen S, Grüttner C, Nguyen-Dinh V, Herker E
J Cell Sci 132(1):jcs217042 2019
doi: 10.1242/jcs.217042 PMID: 30559250

Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE, Hess LU, Poch T, Martrus G, Garcia-Beltran WF, Körner C, Ziegler AE, Richert L, Oldhafer KJ, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M
Gastroenterology 155(5):1366-1371.e3 2018
doi: 10.1053/j.gastro.2018.07.019 PMID: 30031767

Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication
Hofmann S, Krajewski M, Scherer C, Scholz V, Mordhorst V, Truschow P, Schöbel A, Reimer R, Schwudke D, Herker E
Biochim Biophys Acta Mol Cell Biol Lipids 1863(9):1041-1056 2018
doi: 10.1016/j.bbalip.2018.06.002 PMID: 29885363

Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes
Schöbel A, Rösch K, Herker E
Sci Rep 8(1):3893 2018
doi: 10.1038/s41598-018-22243-7 PMID: 29497123 PMCID: PMC5832748

Guidelines and recommendations on yeast cell death nomenclature
Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte- Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F
Microb Cell 5(1):4-31 2018
doi: 10.15698/mic2018.01.607 PMID: 29354647 PMCID: PMC5772036

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
Rösch K, Kwiatkowski M, Schlüter H, Herker E
J Vis Exp (122):55585 2017
doi: 10.3791/55585 PMID: 28448054 PMCID: PMC5564943

Quantitative Lipid Droplet Proteome Analysis Identifies Annexin A3 as a Cofactor for HCV Particle Production
Rösch K, Kwiatkowski M, Hofmann S, Schöbel A, Grüttner C, Wurlitzer M, Schlüter H, Herker E
Cell Rep 16(12):3219-3231 2016
doi: 10.1016/j.celrep.2016.08.052 PMID: 27653686

Unique human immune signature of Ebola virus disease in Guinea
Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C
Nature 533(7601):100-4 2016
doi: 10.1038/nature17949 PMID: 27147028 PMCID: PMC4876960

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse AW, Polywka S, Pischke S, Herker E, Dandri M, Lütgehetmann M
J Hepatol 64(5):1033-1040 2016
doi: 10.1016/j.jhep.2016.01.011 PMID: 26805671

The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets
Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV Jr, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M
J Biol Chem 289(52):35770-80 2014
doi: 10.1074/jbc.M114.587816 PMID: 25381252 PMCID: PMC4276846

Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy
Eggert D, Rösch K, Reimer R, Herker E
PLoS One 9(7):e102511 2014
doi: 10.1371/journal.pone.0102511 PMID: 25019511 PMCID: PMC4094509

Towards tender X-rays with Zernike phase-contrast imaging of biological samples at 50 nm resolution
Vartiainen I, Warmer M, Goeries D, Herker E, Reimer R, David C, Meents A
J Synchrotron Radiat 21(Pt 4):790-4 2014
doi: 10.1107/S1600577514010388 PMID: 24971976

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells
Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M
Mol Cell 52(3):314-24 2013
doi: 10.1016/j.molcel.2013.10.009 PMID: 24207025 PMCID: PMC3936344

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein
Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M
PLoS Pathog 9(4):e1003302 2013
doi: 10.1371/journal.ppat.1003302 PMID: 23593007 PMCID: PMC3623766

Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core
Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV Jr, Ott M
J Biol Chem 288(14):9915-9923 2013
doi: 10.1074/jbc.M112.434910 PMID: 23420847 PMCID: PMC3617291

Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis
Webster B, Wissing S, Herker E, Ott M, Greene WC
J Virol 87(1):581-96 2013
doi: 10.1128/JVI.01047-12 PMID: 23097449 PMCID: PMC3536371

Emerging role of lipid droplets in host/pathogen interactions
Herker E, Ott M
J Biol Chem 287(4):2280-7 2012
doi: 10.1074/jbc.R111.300202 PMID: 22090026 PMCID: PMC3268388

Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis
Harris C, Herker E, Farese RV Jr, Ott M
J Biol Chem 286(49):42615-42625 2011
doi: 10.1074/jbc.M111.285148 PMID: 21984835 PMCID: PMC3234948

Unique ties between hepatitis C virus replication and intracellular lipids
Herker E, Ott M
Trends Endocrinol Metab 22(6):241-8 2011
doi: 10.1016/j.tem.2011.03.004 PMID: 21497514 PMCID: PMC3118981

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M
Nat Med 16(11):1295-8 2010
doi: 10.1038/nm.2238 PMID: 20935628 PMCID: PMC3431199

Induction of autophagy by spermidine promotes longevity
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona- Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F
Nat Cell Biol 11(11):1305-14 2009
doi: 10.1038/ncb1975 PMID: 19801973

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M
EMBO J 28(10):1407-17 2009
doi: 10.1038/emboj.2009.99 PMID: 19387490 PMCID: PMC2688543

Why yeast cells can undergo apoptosis: death in times of peace, love, and war
Büttner S, Eisenberg T, Herker E, Carmona-Gutierrez D, Kroemer G, Madeo F
J Cell Biol 175(4):521-5 2006
doi: 10.1083/jcb.200608098 PMID: 17101700 PMCID: PMC2064587

Physical interaction of apoptosis-inducing factor with DNA and RNA
Vahsen N, Candé C, Dupaigne P, Giordanetto F, Kroemer RT, Herker E, Scholz S, Modjtahedi N, Madeo F, Le Cam E, Kroemer G
Oncogene 25(12):1763-74 2006
doi: 10.1038/sj.onc.1209206 PMID: 16278674

Yeast caspase 1 links messenger RNA stability to apoptosis in yeast
Mazzoni C, Herker E, Palermo V, Jungwirth H, Eisenberg T, Madeo F, Falcone C
EMBO Rep 6(11):1076-81 2005
doi: 10.1038/sj.embor.7400514 PMID: 16170310 PMCID: PMC1371024

A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae
Laun P, Ramachandran L, Jarolim S, Herker E, Liang P, Wang J, Weinberger M, Burhans DT, Suter B, Madeo F, Burhans WC, Breitenbach M
FEMS Yeast Res 5(12):1261-72 2005
doi: 10.1016/j.femsyr.2005.07.006 PMID: 16168721

Viral killer toxins induce caspase- mediated apoptosis in yeast
Reiter J, Herker E, Madeo F, Schmitt MJ
J Cell Biol 168(3):353-8 2005
doi: 10.1083/jcb.200408071 PMID: 15668299 PMCID: PMC2171720

Apoptosis in yeast
Madeo F, Herker E, Wissing S, Jungwirth H, Eisenberg T, Fröhlich KU
Curr Opin Microbiol 7(6):655-60 2004
doi: 10.1016/j.mib.2004.10.012 PMID: 15556039

An AIF orthologue regulates apoptosis in yeast
Wissing S, Ludovico P, Herker E, Büttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Fröhlich KU, Manns J, Candé C, Sigrist SJ, Kroemer G, Madeo F
J Cell Biol 166(7):969-74 2004
doi: 10.1083/jcb.200404138 PMID: 15381687 PMCID: PMC2172025

Chronological aging leads to apoptosis in yeast
Herker E, Jungwirth H, Lehmann KA, Maldener C, Fröhlich KU, Wissing S, Büttner S, Fehr M, Sigrist S, Madeo F
J Cell Biol 164(4):501-7 2004
doi: 10.1083/jcb.200310014 PMID: 14970189 PMCID: PMC2171996

A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast
Mazzoni C, Mancini P, Verdone L, Madeo F, Serafini A, Herker E, Falcone C
Mol Biol Cell 14(2):721-9 Erratum in: Mol Biol Cell 14(4) 2003
doi: 10.1091/mbc.e02-05-0258 PMID: 12589065 PMCID: PMC150003

Apoptosis in yeast: a new model system with applications in cell biology and medicine
Madeo F, Engelhardt S, Herker E, Lehmann N, Maldener C, Proksch A, Wissing S, Fröhlich KU
Curr Genet 41(4):208-16 2002
doi: 10.1007/s00294-002-0310-2 PMID: 12172961

A caspase-related protease regulates apoptosis in yeast
Madeo F, Herker E, Maldener C, Wissing S, Lächelt S, Herlan M, Fehr M, Lauber K, Sigrist SJ, Wesselborg S, Fröhlich KU
Mol Cell 9(4):911-7 2002
doi: 10.1016/s1097-2765(02)00501-4 PMID: 11983181