Publications

Hehner J, Schneider L, Woitalla A, Ott B, Vu KCT, Schöbel A, Hain T, Schwudke D, Herker E. Glycerophospholipid remodeling is critical for orthoflavivirus infection. Nat Commun. 2024 Oct 7;15(1):8683. doi: 10.1038/s41467-024-52979-y. PMID: 39375358; PMCID: PMC11458896.

Schöbel A, Pinho Dos Reis V, Burkhard R, Hehner J, Schneider L, Schauflinger M, Vieyres G, Herker E. Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids. Commun Biol. 2024 Sep 5;7(1):1089. doi: 10.1038/s42003-024-06776-4. PMID: 39237833; PMCID: PMC11377701.

Dos Reis VP, Cirksena K, Rybak-Wolf A, Seeger B, Herker E, Gerold G. 3D Spheroid and Organoid Models to Study Neuroinfection of RNA Viruses. Methods Mol Biol. 2024;2824:409-424. doi: 10.1007/978-1-0716-3926-9_26. PMID: 39039427.

Bley H, Krisp C, Schöbel A, Hehner J, Schneider L, Becker M, Stegmann C, Heidenfels E, Nguyen-Dinh V, Schlüter H, Gerold G, Herker E. Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry. J Biol Chem. 2024 May;300(5):107286. doi: 10.1016/j.jbc.2024.107286. Epub 2024 Apr 16. PMID: 38636657; PMCID: PMC11101947.

Groß R, Reßin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preußer C, Seehafer K, Pöhlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Münch J, Müller JA. Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens. Nat Microbiol. 2024 Apr;9(4):905-921. doi: 10.1038/s41564-024-01637-6. Epub 2024 Mar 25. PMID: 38528146; PMCID: PMC10994849.

Herker E. Lipid Droplets in Virus Replication. FEBS Lett. 2024 May;598(10):1299-1300. doi: 10.1002/1873-3468.14819. Epub 2024 Feb 13. PMID: 38348563.

Nguyen-Dinh V, Herker E. Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses. Cells. 2021 Sep 13;10(9):2407. doi: 10.3390/cells10092407. PMID: 34572055; PMCID: PMC8464962.

Schöbel A, Nguyen-Dinh V, Schumann GG, Herker E. Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells. PLoS Pathog. 2021 Apr 19;17(4):e1009496. doi: 10.1371/journal.ppat.1009496. PMID: 33872335; PMCID: PMC8084336.

Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M. Lipid Droplet Contact Sites in Health and Disease. Trends Cell Biol. 2021 May;31(5):345-358. doi: 10.1016/j.tcb.2021.01.004. Epub 2021 Feb 2. PMID: 33546922.

Horvatits T, Wißmann JE, Johne R, Groschup MH, Gadicherla AK, Schulze Zur Wiesch J, Eiden M, Todt D, Reimer R, Dähnert L, Schöbel A, Horvatits K, Lübke R, Wolschke C, Ayuk F, Rybczynski M, Lohse AW, Addo MM, Herker E, Lütgehetmann M, Steinmann E, Pischke S. Hepatitis E virus persists in the ejaculate of chronically infected men. J Hepatol. 2021 Jul;75(1):55-63. doi: 10.1016/j.jhep.2020.12.030. Epub 2021 Jan 20. PMID: 33484776.

Beller M, Herker E, Füllekrug J. Grease on-Perspectives in lipid droplet biology. Semin Cell Dev Biol. 2020 Dec;108:94-101. doi: 10.1016/j.semcdb.2020.06.017. Epub 2020 Jul 4. PMID: 32636101.

Bley H, Schöbel A, Herker E. Whole Lotta Lipids-from HCV RNA Replication to the Mature Viral Particle. Int J Mol Sci. 2020 Apr 21;21(8):2888. doi: 10.3390/ijms21082888. PMID: 32326151; PMCID: PMC7215355.

Lassen S, Grüttner C, Nguyen-Dinh V, Herker E. Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production. J Cell Sci. 2019 Jan 9;132(1):jcs217042. doi: 10.1242/jcs.217042. PMID: 30559250.

Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE, Hess LU, Poch T, Martrus G, Garcia-Beltran WF, Körner C, Ziegler AE, Richert L, Oldhafer KJ, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M. Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. Gastroenterology. 2018 Nov;155(5):1366-1371.e3. doi: 10.1053/j.gastro.2018.07.019. Epub 2018 Jul 19. PMID: 30031767.

Hofmann S, Krajewski M, Scherer C, Scholz V, Mordhorst V, Truschow P, Schöbel A, Reimer R, Schwudke D, Herker E. Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1041-1056. doi: 10.1016/j.bbalip.2018.06.002. Epub 2018 Jun 6. PMID: 29885363.

Schöbel A, Rösch K, Herker E. Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes. Sci Rep. 2018 Mar 1;8(1):3893. doi: 10.1038/s41598-018-22243-7. PMID: 29497123; PMCID: PMC5832748.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte- Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. PMID: 29354647; PMCID: PMC5772036.

Rösch K, Kwiatkowski M, Schlüter H, Herker E. Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis. J Vis Exp. 2017 Apr 17;(122):55585. doi: 10.3791/55585. PMID: 28448054; PMCID: PMC5564943.

Rösch K, Kwiatkowski M, Hofmann S, Schöbel A, Grüttner C, Wurlitzer M, Schlüter H, Herker E. Quantitative Lipid Droplet Proteome Analysis Identifies Annexin A3 as a Cofactor for HCV Particle Production. Cell Rep. 2016 Sep 20;16(12):3219-3231. doi: 10.1016/j.celrep.2016.08.052. PMID: 27653686.

Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C. Unique human immune signature of Ebola virus disease in Guinea. Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949. PMID: 27147028; PMCID: PMC4876960.

Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse AW, Polywka S, Pischke S, Herker E, Dandri M, Lütgehetmann M. Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation. J Hepatol. 2016 May;64(5):1033-1040. doi: 10.1016/j.jhep.2016.01.011. Epub 2016 Jan 22. PMID: 26805671.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV Jr, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26;289(52):35770-80. doi: 10.1074/jbc.M114.587816. Epub 2014 Nov 7. PMID: 25381252; PMCID: PMC4276846.

Eggert D, Rösch K, Reimer R, Herker E. Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy. PLoS One. 2014 Jul 11;9(7):e102511. doi: 10.1371/journal.pone.0102511. PMID: 25019511; PMCID: PMC4094509.

Vartiainen I, Warmer M, Goeries D, Herker E, Reimer R, David C, Meents A. Towards tender X-rays with Zernike phase-contrast imaging of biological samples at 50 nm resolution. J Synchrotron Radiat. 2014 Jul;21(Pt 4):790-4. doi: 10.1107/S1600577514010388. Epub 2014 Jun 11. PMID: 24971976.

Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 7;52(3):314-24. doi: 10.1016/j.molcel.2013.10.009. PMID: 24207025; PMCID: PMC3936344.

Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PMID: 23593007; PMCID: PMC3623766.

Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV Jr, Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 5;288(14):9915-9923. doi: 10.1074/jbc.M112.434910. Epub 2013 Feb 18. PMID: 23420847; PMCID: PMC3617291.

Webster B, Wissing S, Herker E, Ott M, Greene WC. Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol. 2013 Jan;87(1):581-96. doi: 10.1128/JVI.01047-12. Epub 2012 Oct 24. PMID: 23097449; PMCID: PMC3536371.

Herker E, Ott M. Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem. 2012 Jan 20;287(4):2280-7. doi: 10.1074/jbc.R111.300202. Epub 2011 Nov 16. PMID: 22090026; PMCID: PMC3268388.

Harris C, Herker E, Farese RV Jr, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 9;286(49):42615-42625. doi: 10.1074/jbc.M111.285148. Epub 2011 Oct 7. PMID: 21984835; PMCID: PMC3234948.

Herker E, Ott M. Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab. 2011 Jun;22(6):241-8. doi: 10.1016/j.tem.2011.03.004. Epub 2011 Apr 15. PMID: 21497514; PMCID: PMC3118981.

Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov;16(11):1295-8. doi: 10.1038/nm.2238. Epub 2010 Oct 10. PMID: 20935628; PMCID: PMC3431199.

Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona- Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. PMID: 19801973.

Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. EMBO J. 2009 May 20;28(10):1407-17. doi: 10.1038/emboj.2009.99. Epub 2009 Apr 23. PMID: 19387490; PMCID: PMC2688543.

Büttner S, Eisenberg T, Herker E, Carmona-Gutierrez D, Kroemer G, Madeo F. Why yeast cells can undergo apoptosis: death in times of peace, love, and war. J Cell Biol. 2006 Nov 20;175(4):521-5. doi: 10.1083/jcb.200608098. Epub 2006 Nov 13. PMID: 17101700; PMCID: PMC2064587.

Vahsen N, Candé C, Dupaigne P, Giordanetto F, Kroemer RT, Herker E, Scholz S, Modjtahedi N, Madeo F, Le Cam E, Kroemer G. Physical interaction of apoptosis-inducing factor with DNA and RNA. Oncogene. 2006 Mar 16;25(12):1763-74. doi: 10.1038/sj.onc.1209206. PMID: 16278674.

Mazzoni C, Herker E, Palermo V, Jungwirth H, Eisenberg T, Madeo F, Falcone C. Yeast caspase 1 links messenger RNA stability to apoptosis in yeast. EMBO Rep. 2005 Nov;6(11):1076-81. doi: 10.1038/sj.embor.7400514. Epub 2005 Sep 9. PMID: 16170310; PMCID: PMC1371024.

Laun P, Ramachandran L, Jarolim S, Herker E, Liang P, Wang J, Weinberger M, Burhans DT, Suter B, Madeo F, Burhans WC, Breitenbach M. A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae. FEMS Yeast Res. 2005 Dec;5(12):1261-72. doi: 10.1016/j.femsyr.2005.07.006. Epub 2005 Aug 31. PMID: 16168721.

Reiter J, Herker E, Madeo F, Schmitt MJ. Viral killer toxins induce caspase- mediated apoptosis in yeast. J Cell Biol. 2005 Jan 31;168(3):353-8. doi: 10.1083/jcb.200408071. Epub 2005 Jan 24. PMID: 15668299; PMCID: PMC2171720.

Madeo F, Herker E, Wissing S, Jungwirth H, Eisenberg T, Fröhlich KU. Apoptosis in yeast. Curr Opin Microbiol. 2004 Dec;7(6):655-60. doi: 10.1016/j.mib.2004.10.012. PMID: 15556039.

Wissing S, Ludovico P, Herker E, Büttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Fröhlich KU, Manns J, Candé C, Sigrist SJ, Kroemer G, Madeo F. An AIF orthologue regulates apoptosis in yeast. J Cell Biol. 2004 Sep 27;166(7):969-74. doi: 10.1083/jcb.200404138. Epub 2004 Sep 20. PMID: 15381687; PMCID: PMC2172025.

Herker E, Jungwirth H, Lehmann KA, Maldener C, Fröhlich KU, Wissing S, Büttner S, Fehr M, Sigrist S, Madeo F. Chronological aging leads to apoptosis in yeast. J Cell Biol. 2004 Feb 16;164(4):501-7. doi: 10.1083/jcb.200310014. PMID: 14970189; PMCID: PMC2171996.

Mazzoni C, Mancini P, Verdone L, Madeo F, Serafini A, Herker E, Falcone C. A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast. Mol Biol Cell. 2003 Feb;14(2):721-9. doi: 10.1091/mbc.e02-05-0258. Erratum in: Mol Biol Cell. 2003 Apr;14(4):following 1743. PMID: 12589065; PMCID: PMC150003.

Madeo F, Engelhardt S, Herker E, Lehmann N, Maldener C, Proksch A, Wissing S, Fröhlich KU. Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr Genet. 2002 Jul;41(4):208-16. doi: 10.1007/s00294-002-0310-2. Epub 2002 Jul 5. PMID: 12172961.

Madeo F, Herker E, Maldener C, Wissing S, Lächelt S, Herlan M, Fehr M, Lauber K, Sigrist SJ, Wesselborg S, Fröhlich KU. A caspase-related protease regulates apoptosis in yeast. Mol Cell. 2002 Apr;9(4):911-7. doi: 10.1016/s1097-2765(02)00501-4. PMID: 11983181.